A potential link with plasma triglycerides could be made by the assumption that DPP4 may inhibits the effect of the incretin hormone glucose-dependent insulinotropic polypeptide on lipoprotein lipase synthesis and activity in adipocytes [23,24], which would favor hypertriglyceridemia due to lower triglyceride hydrolysis as seen in lipoprotein lipase deficiency [25]. This evidence concerns the gene GCG and hypertriglyceridemia.