Ovarian and cervical cancers have been reported to exhibit an upregulated expression of HLA-E, a ligand for the inhibitory CD94/NKG2A complex and the upregulation of HLA-E and the infiltration of cytolytic T cell populations could be neutralized by strong overexpression of the NKG2A ligand (Gooden et al., 2011). The gene discussed is HLA-E; the disease is cervical cancer.