CD274 and neoplasm: (2) Secretion of anti-inflammatory mediators such as TGF-β and indoleamine 2,3-dioxygenase (IDO) converts conventional (naïve) T cells to Treg cells, either directly or via the actions of antigen-presenting cells; (3) A selective survival advantage of Treg cells over other tumor-infiltrating lymphocytes occurs when negative costimulatory signals selectively influence effector T cells (PD-L1, FasL).