Although one study reports that Hsp70 release from prostate cancer cells protects against tumor growth (Wang et al., 2004), presumably via its capacity to induce tumor-specific immunity (Calderwood et al., 2005, 2006), Hsp70 might also adversely influence anti-tumor immunity by activating CD4+CD25high Treg cells via its capacity to interact with TLRs expressed thereon. This evidence concerns the gene CD4 and neoplasm.