KLRD1 and neoplasm: Membrane Hsp70 acts as a tumor-specific recognition structure for CD94+ NK cells and, in the presence of Hsp70 and cytokine (IL-2/IL-15) co-activation, it enhances the capacity of NK cells these cells to kill membrane Hsp70 positive tumor cells (Botzler et al., 1996, 1998; Gross et al., 2003a,b).