Activating KIRs may be relevant for recognition and killing of leukemia cells and dendritic cells (DCs; see below), while CD94/NKG2C appears to be involved in the control of HCMV infections (Gumà et al., 2004; Della Chiesa et al., 2012; Foley et al., 2012). The gene discussed is KLRD1; the disease is leukemia.