Some studies have shown that eosinophils isolated from patients with eosinophilia degranulate in response to anti-IgE antibody (Moqbel et al., 1990) and that a high-affinity IgE receptor is present on eosinophils from patients with eosinophilia and various effector functions are mediated through this receptor (Moqbel et al., 1990; Gounni et al., 1994). This evidence concerns the gene IGHE and Increased total eosinophil count.