Other studies have shown that eotaxin plays an important role in initiating both blood and tissue eosinophilia in the early phase of allergic inflammation (Schuh et al., 2002), while IL-5 is essential for eotaxin-induced tissue eosinophilia (Collins et al., 1995; Rothenberg et al., 1996; Mould et al., 1997). This evidence concerns the gene IL5 and Increased total eosinophil count.