IL10 and irritable bowel syndrome: As an example, patients with IBS had significantly reduced frequencies of the high producer genotype for interleukin 10 than controls (21 vs. 32%; p = 0.003): this suggests a genetic predisposition in at least some patients with IBS to produce lower amounts of the anti-inflammatory cytokine interleukin 10 (Gonsalkorale et al., 2003) and lends support to the hypothesis that there may be an inflammatory or genetic component in some cases of IBS (Bashashati et al., 2012).