LTBP2 and glaucoma secondary to spherophakia/ectopia lentis and megalocornea: Recently, homozygous mutations in LTBP2 were reported in a syndrome of megalocornea, microspherophakia (small spherical lens), lens dislocation, and secondary glaucoma developing after age 3 years [29] and in isolated microspherophakia/lens dislocation [30].