MC4R and obesity due to melanocortin 4 receptor deficiency: Furthermore, we found nominal association between risk of obesity and both ENPP1 rs7754561 (G risk allele; OR = 0.84[0.72;0.97]; P = 0.020; Table 2) and MC4R rs17782313 (C risk allele; OR = 1.40[1.06;1.83]; P = 0.016; Table 2).