There were significant differences between the GPS groups in age (P=0.048), AST (P<0.0001), ALT (P=0.017), T-Bil (P<0.0001), PT (P = 0.022), AFP (P=0.008), maximal tumor diameter (P=0.003), tumor number (P=0.041), frequency of vascular invasion (P=0.0002), and frequency of extra hepatic metastasis (P=0.02). The gene discussed is AFP; the disease is neoplasm.