We investigated the role of MyD88-dependent innate immune responses in the regulation of parasite and cell infiltration into the brain, which are a major pathogenic event of infection with T. gondii, by using infected BALB/c mice which develop an acute infection with little sign of diseases, either control infection and become latently infected with no clinical symptoms but form cysts in the brain as occurs in immunocompetent humans. Here, MYD88 is linked to infection.