Of the 15 of 21 connexin isotypes (Cx23, Cx26, Cx30, Cx30.2, Cx30.3, Cx31, Cx31.1, Cx32, Cx36, Cx37, Cx43, Cx45, Cx46, Cx50 and Cx62) tested in a pilot study Cx26, Cx32, Cx43 and Cx46 were detected reliably and widespread in breast cancers. The gene discussed is GJB1; the disease is breast carcinoma.