In order to elucidate whether such a MST-FOXO signaling mechanism contributes to modulating the subcellular localization and activity of FOXO3a during the pathogenic process of neurogenic muscle atrophy, we examined the phosphorylation status of FOXO3a at Ser207 in both WT and MST1 deficient TA muscles undergoing atrophy. Here, FOXO3 is linked to Skeletal muscle atrophy.