Subsequently, all clinicopathological characteristics including age, ER/PR status, HER2/neu status, histologic tumor type, pathologic tumor size, histologic tumor grade and axillary lymph node status were enrolled in multivariate survival analysis, which showed that the expression of GGH protein still retained its significance as an independent prognostic factor for unfavorable DSS (95% CI: 1.3–10.3, P = 0.02; Table 5). This evidence concerns the gene GGH and neoplasm.