The two genes selected from the RSL were significantly down-regulated in the tumor tissues as compared with the adjacent nonmalignant lung tissues (GPX3, P = 0.000 and TIMP3, P = 0.000), and six genes selected from the FSL were significantly up-regulated in the lung cancer tissues (DDR1, P = 0.009; HSP90B1, P = 0.000; SDC1, P = 0.007; RPSA, P = 0.013; ERGIC3, P = 0.000; and LPCAT1 P = 0.036). This evidence concerns the gene TIMP3 and lung cancer.