Formica et al. [22] reported that VEGF -1154 G/A was an independent prognostic factor for PFS, and VEGF −634 G/C was significantly associated with the response rate in patients with metastatic colorectal cancer patients receiving first-line treatment including fluorouracil, irinotecan, and bevacizumab. The gene discussed is VEGFA; the disease is metastatic colorectal cancer.