In conclusion, AT1R-deficiency or pharmacological inhibition of the AT1R and activation of PPARγ with telmisartan in diabetic individuals have beneficial effects on oxidative stress, endothelial function and atherosclerotic plaque development especially in metabolic and RAAS abnormalities associated with diabetes indicating to a relevant interaction of PPARγ and the RAAS in vivo. This evidence concerns the gene PPARG and diabetes mellitus.