MYCN and neuroblastoma: This change in nuclear size can be seen in Figure 3A, in which MYCN transfection into the NB cell line SK-N-AS (clone 14.2) results in cells with a relative nuclear size twice that of the parental or control-transfected (8B) cell lines which contain a single copy of MYCN and do not express MYCN mRNA (Figure 3B).