In NB, a genome-wide assessment of MYCN using the tetracycline (TET) suppressible MYCN SHEP NB model system and ChIP hybridizations to gene promoters (ChIP-Chip) revealed that MYCN binding associates with euchromatic histone marks H3K4me and H3K9Ac (Cotterman et al., 2008). This evidence concerns the gene MYCN and neuroblastoma.