STAT3 and neoplasm: Interestingly, chemical inhibition of JAK2 phosphorylation with AG490 vigorously induced apoptosis in all four cell lines (Fig. S1A), and inhibited the expression of STAT3 and its downstream proteins such as MCL1 and survivin (Fig. S1B), thus indicating that inhibition of the JAK2/STAT3 pathway plays a crucial role in the anti-tumour activities of resveratrol against malignant NK cells.