In addition, NK cells pre-cultured with or without pifithrin α, a p53 inhibitor which is by itself non-toxic to the NK cell lines (Fig. S2), were equally susceptible to resveratrol-induced apoptosis (Fig. 5B), indicating that functional p53 is not required for resveratrol anti-tumour activity against malignant NK cells. Here, TP53 is linked to neoplasm.