The active Bac-ELP1-H1 polypeptide, or control polypeptides lacking the H1 peptide (Bac-ELP1) or utilizing the non-thermally responsive version of ELP (Bac-ELP2-H1) were injected IV, and, in hyperthermia groups, hyperthermia was applied to the tumor site using the thermal cycling protocol immediately after each injection. This evidence concerns the gene ELP1 and neoplasm.