Stratified by histology, the combined HR of the 16 studies reporting NSCLC as a whole indicated that patients with p16 hypermethylation had a risk of death 1.41 times greater than patients without p16 hypermethylation (HR = 1.41, 95% CI: 1.10–1.79). This evidence concerns the gene CDKN2A and non-small cell lung carcinoma.