PROK2 and neoplasm: As shown in Figure 1C–F, a notable decrease in relative blood vessel density and a significant increase in areas of necrotic regions of the PKRA7-treated tumors were observed in comparison to controls, suggesting that PKRA7 may suppress tumor formation primarily by inhibiting angiogenesis through PKR1 and PKR2 expressed on endothelial cells in a similar fashion as the PK2-neutrolizing antibodies [8], [12]–[13].