PROK2 and pancreatic neoplasm: Importantly, at least four of these induced molecules are known to be involved in enhancing the migration of myeloid cells and all of their induction by PK2 was blunted by PKRA7 (Figure 3F), strongly suggesting that suppression of the PK2-induced production of these chemokines and receptors underlies the primary mechanism of anti-tumor activity of PKRA7 in the context of pancreatic cancer.