A very recent study by Yao et al., shows that perifosine induces cell apoptosis in human osteosarcoma cells, perifosine blocks Akt/mTOR complex 1 (mTORC1) signaling and inhibits survivin expression by disrupting their association with heat shock protein-90 (HSP-90) [51]. Here, BIRC5 is linked to osteosarcoma.