Further, our groups [16], [54] and others have demonstrated that multiple anti-cancer chemotherapies including vincristine [55], [56], taxol [52], [57], temozolomide [58], and doxorubicin [16], [59], as well as natural anti-cancer plant extracts including ursolic acid [60], Honokiol [61], widdrol [62], EGCG [63], quercetin [64] and fisetin [65] all activate AMPK to promote cancer cell death. This evidence concerns the gene PRKAA1 and cancer.