MICA is also a ligand for NKG2D on γδ T cells, which have been shown to increase neutralizing antibodies in the absence of CD4 αβ T cells against vesicular stomatitis virus (VSV), foot-and-mouth disease virus, as well as Borrelia burgdorferi, the causative agent for lyme disease [31]–[33]. This evidence concerns the gene KLRK1 and Lyme disease.