These data indicate that the interaction of VLA-4/VCAM-1 seems to be crucial for the rolling and adhesion of leukocytes to the site of injury in this adoptive transfer model of diabetes in NOD mice and the CD11b or lymphocyte function associated antigen 1 (LFA-1) interaction with ICAM-1 has less impact in this mouse model. The gene discussed is VCAM1; the disease is diabetes mellitus.