JAM3 and type 1 diabetes mellitus: Nevertheless, the blocking studies in RIP-LCMV mice suggest that JAM-C plays a certain role in the pathogenesis of T1D, since neutralization of JAM-C resulted in a reversion of T1D in some diabetic RIP-LCMV-GP mice (fast-onset model) and a reduction of mean blood glucose levels and overall T1D incidence RIP-LCMV-NP mice (slow-onset model).