We have demonstrated in the past that blockade of critical chemokines, such as CXCL10 (IP-10, IFNγ-inducible protein of 10 kDa), results in the abrogation of T1D in the RIP-LCMV model [1] indicating that cellular attraction to the islet of Langerhans is a critical step required for the subsequent destruction of insulin-producing β-cells. Here, INS is linked to type 1 diabetes mellitus.