We further hypothesized that down-regulation of FoxM1 signaling by DIM and Herceptin will induce apoptotic cell death, which could be due to inactivation of FoxM1 directly and indirectly via inactivation of Akt and NF-κB. However, a more detailed understanding of the effects of this drug combination and its mechanism of action in HER-2/neu-expressing breast cancer is needed. This evidence concerns the gene AKT1 and breast cancer.