Conversely, transfection with FoxM1 siRNA in both SKBR3 and MDA-MB-468 cell lines showed inhibitory effects on FoxM1, NF-κb p65 and pAkt, although more significant effects were observed in SKBR3 suggesting that DIM enhances Herceptin activity in breast cancer cells, but significant effect was found in HER-2/neu-expressing breast cancer cells. This evidence concerns the gene NFKB1 and breast cancer.