IL6R and plasma cell neoplasm: Levels of IL6 have a significant impact on the prognosis of other IL6-related diseases and malignancies, including plasma cell dyscrasias (PCD).[8]–[10] Single nucleotide polymorphisms (SNPs) in the IL6 signaling pathway have been studied in acute phase reaction, auto-immune phenomena, and malignancies, and have been linked to elevated IL6 production.[11]–[14] Increased levels of IL6, along with soluble IL6R (sIL6R), have been detected in the synovial fluid of patients with rheumatoid arthritis [5], [6], [15].