The remaining 15 genes included in the current screen were of interest as a result of our previous studies that elucidated the role of IGF1R and KIT signaling in the pathogenesis of GIST, i.e., SPRY2 & 4, SPRED1 & 2, FBXO32, IGF1R, IGF2R, IGF1 & 2 and IGFBP1–6 (Table S3) [10], [11], [34]. This evidence concerns the gene SPRED1 and gastrointestinal stromal tumor.