Since FXR is a robust mediator of innate host defense in the intestine [3] and colon expression of FXR mRNA is reduced in IBDs [19] we have next investigated the colonic expression of FXR in a murine model colitis induced by TNBS administration to wild type (C57BL/6) and TLR2−/−, TLR4−/−, TLR9−/− and MyD88−/− mice. Here, NR1H4 is linked to colitis.