MACROH2A1 and fatty liver disease: MacroH2A1 knock out (KO) mice display hepatic steatosis and derangements in glucose and lipid metabolism [16], [17] and, interestingly, when wild type mice are fed a methyl-deficient diet, which induce a fatty liver and inflammation, a total increase in the hepatic content of macroH2A1 is observed [18].