CCN2 and colonic neoplasm: Also co-regulated with TAZ-AXL-CTGF were genes involved in EMT, migration and invasion, colon cancer progression, calcium signaling, angiogenesis, cytoskeleton association, membrane trafficking, focal adhesion, Hippo pathway regulation, and MMPs inhibition (Tables 1 and 2), suggesting that these biological processes may play an important role in TAZ-AXL-CTGF-mediated colon cancer progression.