Colon cancer biomarkers were also differentially expressed in these two groups of patients (Tables 1 and 2), namely EFEMP2, a serum biomarker for early detection of colon cancer [65] and SULF1, a protein important in colon cancer diagnosis [66] and whose serum level is elevated in patients with colon adenomas [67]. This evidence concerns the gene SULF1 and malignant colon neoplasm.