WWTR1 and malignant colon neoplasm: Interestingly, ZEB1 has been shown to be a downstream target of TAZ in retinal pigment epithelial cells [57], suggesting that ZEB1 may act as a downstream effector of TAZ to promote cancer metastasis, while ZEB1 and ZEB2 have also been shown to be prognostic markers in colon cancer [53], [56].