Mutations in adherens junction proteins like crumbs 1 (CRB1) are associated with blinding diseases such as retinitis pigmentosa (RP) and Leber congenital amaurosis (LCA) [8], and ablation of proteins involved in the formation of adherens junctions like N-cadherin or catenins lead to severe retinal disorganization [8]–[11]. The gene discussed is CDH2; the disease is Leber congenital amaurosis.