Platelets chemokines (e.g. RANTES, PF4, SDF-1, MCP-1, CXCL5, CXCL7) and newly synthesized active cytokine-like factors [e.g. IL-1β, CD40 ligand (CD40L), β-thromboglobulin] are implicated in the development of atherosclerosis [41], [42], [43]. This evidence concerns the gene PPBP and atherosclerosis.