Consequently, the IL-12 pretreatment markedly aggravated hepatitis, as shown by the increased ALT levels after α-GalCer injection in HFCD mice compared to control mice (7, 500 v.s 1, 600), and the FasL expression on NKT cells was obviously increased in the HFCD mice compared to that of CD mice (Fig. 11d). This evidence concerns the gene FASLG and hepatitis A virus infection.