Several studies have pointed to the potential use of PI3K/AKT inhibitors in suppressing tumor growth in vitro, in vivo as well as in chemo-sensitization (Brognard et al., 2001; Stassi et al., 2005; Sinnberg et al., 2009; Hirai et al., 2010; Isosaki et al., 2011). Here, PIK3CA is linked to neoplasm.