Mutations in BRAF are prevalent in human cancers (7%) with the highest incidences found in malignant melanoma (27–70%), papillary thyroid cancer (36–53%), colorectal cancer (5–22%), and serous ovarian cancer (30%; Davies et al., 2002; Kumar et al., 2003; Pollock et al., 2003a; Young et al., 2005). This evidence concerns the gene BRAF and melanoma.