BRAF and melanoma: Vemurafenib (PLX4720/RG7204), a novel BRAF inhibitor with high specificity to BRAFV600E has potent cytotoxicity against melanoma cells in vitro and in vivo and clinically has improved survival of melanoma patients (Tsai et al., 2008; Yang et al., 2010; Chapman et al., 2011; Young et al., 2012).