AKT1 and cancer: Dysregulation of the PI3K/AKT pathway in cancer can occur as result of mutations in the gene encoding the p110 catalytic subunit of PI3K, PI3KCA subunit (Samuels et al., 2004), loss of the tumor suppressor PTEN, a negative regulator of PI3K/AKT pathway (Li et al., 1997) or molecular alterations in AKT (Staal, 1987; Bellacosa et al., 1995; Cheung et al., 2008).