Germ line INK4A mutations (Hussussian et al., 1994; Kamb et al., 1994), polymorphisms in the 5′ and 3′ untranslated regions (UTRs) that alter translation or regulate mRNA stability of p16INK4A and promoter mutations of p16INK4A are all genomic alterations that have also been identified in association with 9p21-linked familial melanoma (Liu et al., 1999; Kumar et al., 2001). The gene discussed is CDKN2A; the disease is familial melanoma.