Specific miRNA expressionprofiles have been defined in major subtypes of ALL (T-cell, MLL-rearranged,TEL–AML1-positive, E2A-PBX1-positive, and hyper-diploid acute lymphoblasticleukemia) and identified as highly predictive of clinical outcome (Schotte et al., 2011). Here, RUNX1 is linked to acute lymphoblastic leukemia.