As tumor suppressor, miR-181a targets RalA associated with cellproliferation, G2-phase arrest, and apoptosis in CML (Fei etal., 2012).Eiring et al. (2010) demonstrateda RISC-independent decoy activity for miR-328, which is down-regulated in CML blast crisis(CML-BC). The gene discussed is RALA; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.