Moreover, miR-17-92 areoverexpressed for transactivation induced by both breakpoint cluster region-c-abl oncogene(BCR/ABL) and c-Myc in primary CML CD34+ cells in chronic phase compared with normal CD34+cells (Venturini et al., 2007), and are regulated bymembers of the E2 transcription factor family in a negative feedback loop (O’Donnell et al., 2005). The gene discussed is BCR; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.