On the other hand, a tumor-specific cytotoxic T cell clone isolated from tumor infiltrating lymphocytes in an NSCLC patient expressed KIR3DL2 but not other KIRs, and KIR3DL2 had neither stimulating or inhibiting effect on its cytotoxic or interferon-gamma secreting activity (Dorothée et al., 2003). This evidence concerns the gene KIR3DL2 and neoplasm.