CASP3 and breast cancer: Among the others, we can here remember the role of the protease Caspase-3, frequently associated to high grade BC [79, 92, 93]; Fas, a death receptor which is down-regulated in many BC samples [94, 95]; Bcl-2, an anti-apoptotic protein which is up-regulated in one third of the RC specimens and that is able to promote chemotherapy resistance in neoplastic cells [92]; and Survivin, another inhibitor of apoptosis acting on caspases and promoting tumor cell invasion; Survivin is up-regulated in BC, especially in high grade tumors [96-98].