BIRC2 and breast cancer: Another good candidate as a molecular BC marker in this group is cellular inhibitor of apoptosis protein 1 (cIAP1), belonging to the same protein family (IAPs) of Survivin; cIAP1 is a nuclear shuttling protein able to block both the intrinsic and the extrinsic apoptotic pathways by inhibiting caspases activity; indeed, cIAP1 over-expression is highly correlated with BC recurrence, progression, resistance to chemotherapy and poor prognosis in MIBC [99].