Many studies demonstrate that altered function of this gene, as well as that of its relative TP63 [75], either because of a mutation in the coding sequence or for alterations in its regulation, may be predictive of a poor outcome in both NMIBC and MIBC; moreover, the levels of the TP53 protein increase in normal urothelium to NMIBC to CIS to MIBC to metastatic BC [76-78]. The gene discussed is TP53; the disease is breast cancer.