In another study [42], microarray analysis of the frontal cortex of 15 patients with sporadic CJD revealed the involvement of 79 up-regulated (e.g., metallothionein-1 and 2) and 275 down-regulated genes (e.g., Synaptosomal-associated protein 25 (SNAP25) modulating synaptic function and plasticity) compared to healthy controls. Here, SNAP25 is linked to sporadic Creutzfeldt-Jakob disease.