It is commonly inherited as autosomal recessive and it is caused by mutations in anyone of 14 genes (AIPL1, CABP4, CEP290, CRB1, CRX, GUCY2D, IQCB1, KCNJ13, LCA5, LRAT, RD3, RDH12, RPE65, RPGRIP1, SPATA7, TULP1); the rarer autosomal dominant form of LCA results from mutations in any of 3 genes (CRX, IMPDH1, OTX2). The gene discussed is RPE65; the disease is Leber congenital amaurosis.