Subretinal injection of adeno-associated virus encoding sFLT01 (AAV5.sFLT01) in Ccl2(-/-)/Cx3cr1(-/-) mice, a model for age-related macular degeneration (AMD) resulted in lower levels of A2E, the major component of lipofuscin, in better photoreceptor preservation and downregulation of retinal extracellular signal-regulated kinase (ERK) phosphorylation and inducible nitric oxide synthetase expression [138]. The gene discussed is CCL2; the disease is age-related macular degeneration.