Mutations in two other genes are associated with POAG, specifically mutations in the OPTN gene, which encodes optneurin a protein involved in regulation of membrane trafficking and cellular morphogenesis, and mutations in the WDR36 gene, which encodes a member of the WD repeat protein family involved in multi-protein complexes, signal transduction and gene regulation. The gene discussed is WDR36; the disease is open-angle glaucoma.