INS and myocardial infarction: On multivariate analysis, after adjusting for age, gender, prior myocardial infarction, and chronic administration of aspirin, clopidogrel, insulin, oral hypoglycemic agents, beta-blockers and calcium channel blockers, CXCL12 remained the only factor that was strongly and inversely associated with statin dose at the 95% level (p=0.011).