A recent study has shown that fibroblast cells derived from patients with limb-girdle muscular dystrophy type 2D (LGMD2D) can be converted to iPS cells by overexpression of the reprogramming factors OCT3/4, KLF4, SOX2 and cMYC (the so-called ‘Yamanaka factors’). The gene discussed is MYC; the disease is autosomal recessive limb-girdle muscular dystrophy type 2D.