The role of BCL-2 in tumorigenesis was further confirmed in Eμ-Myc/Eμ-Bcl-2 double transgenic mice where mice that overexpressed both MYC and BCL-2 became terminally ill from leukemia within 50 days while mice that solely expressed MYC required up to 100 days to succumb to malignancy [64]. This evidence concerns the gene MYC and leukemia.