Apart from the recently described cytokine regimens that showed the feasibility of in vitro expansion of blood-isolated MDSCs populations [46] the induction of human MDSCs has been proven a feasible in vitro approach for the generation of CD14+HLADRneg/low MDSCs by differentiation of isolated CD14+ cells in the presence of IL-4 + GM-CSF and tumor-derived microvesicles [46]. The gene discussed is CD14; the disease is neoplasm.