Angiopoietin-2 (ANGPT2) has been implicated in pulmonary vascular leak syndromes including ALI and sepsis in both animal and human studies [39,40], while recently, two ANGPT2 SNPs (rs2442598 and rs1868554) were found to be strongly associated with the development of ALI in patients with major trauma [31]. This evidence concerns the gene ANGPT2 and acute respiratory distress syndrome.