Viable fecal counts of Lactobacillus species, Child-Pugh class, plasma retention rate of indocyanine green (ICGR15), whole blood tumour necrosis factor alpha (TNF--6 (IL-6) mRNA, serum TNF-α, soluble TNFreceptor (sTNFR)I, sTNFRII and IL-6 and plasma endotoxin levels were measured pre- and post-treatment: Synbiotic treatment was associated with significantly increased faecal lactobacilli counts and significant improvements in plasma retention rate of indocyanine green (ICGR15) and stage of liver disease (Child-Pugh classification). This evidence concerns the gene IL6 and liver disorder.