In the improvement of early diagnosis of pancreatic cancer, proteomic application using serum/plasma has revealed over expression of Alpha-1B-glycoprotein precursor, Anterior gradient 2, Apolipoprotein C-I, DJ-1, Fibrinogen β chain, HSP27 and under expression of Apolipoprotein A-II, Caldecrin, CXCL7. The gene discussed is A1BG; the disease is familial pancreatic carcinoma.