Among them, PRKACA is shared by Type II diabetes mellitus, Insulin signaling pathway and Calcium signaling pathways; PIK3R1 is a common molecule of AKT signaling, Insulin signaling and Type II diabetes mellitus pathways; PRKCA is a component for both of Calcium signaling and g-Secretase mediated ErbB4 signaling pathways while PLCG1 for Calcium signaling pathway, PTPN11 for Adipocytokine signaling pathway and GRB2 for Insulin signaling pathway. This evidence concerns the gene GRB2 and type 2 diabetes mellitus.