Although, high levels of MYC are expressed as a result of the t(8;14) and its variant translocations in Burkitt’s lymphoma and in some other B-cell malignancies including DLBCL and plasma cell myeloma, these translocations may not necessarily lead to increased expression of MYC in CLL [4,6,7]. The gene discussed is MYC; the disease is diffuse large B-cell lymphoma.