Both inhibitors were found to be less effective at inhibiting the growth of pancreatic cancer cell lines compared to IGF-IR inhibitor NVP-AEW541, with IC50s ranging from 2.3 μM (Capan-1) to 13.7 μM (PANC1) for MAPKK inhibitor and 5.5 μM (AsPc-1) to 11.3 μM (PANC1) for the PI3K inhibitor (Table 1). Here, IGF1R is linked to familial pancreatic carcinoma.