NR0B1 and alternating hemiplegia of childhood: These types of mutations frequently cause disease.Since the initial identification of DAX1 as the gene responsible for AHC, numerous additional mutations have been discovered including deletions, alterations of splice-sites, missense mutations, nonsense mutations and frame shift mutations (4,7,11,15,16,17,18,19,20,21,22,23,24,25,26,27).