SNCA and dementia: Alpha-synuclein, and the detection of its monomeric and oligomeric species in cerebrospinal fluid and blood of patients with dementia with Lewy bodies, is also the central focus of the review provided by Kasuga et al. The authors conclude that the determination of altered alpha-synuclein species such as truncated, phosphorylated, and oligomeric forms in body fluids may have a far higher potential to differentiate between healthy and disease state compared to the measurement of unaltered alpha-synuclein levels.